Renal dysplasia in dogs is a severe kidney disease that causes great suffering for the affected individual. The disease disturbs the development of the kidneys which leads to an immature microscopic structure of the kidney and smaller kidneys than normal. A dog with Renal dysplasia only lives between 4 and 24 months, because of kidney failure. There are different ways to establish a diagnosis, but the most common way today is to take a renal biopsy. In a scientific study, ultrasound based diagnosis was shown to match the histopathological picture of the disease.

Renal dysplasia is a developmental anomaly of the kidneys which is considered to be the primary lesion in juvenile progressive nephropathy, a condition leading to chronic renal failure in young dogs. It is defined as disorganised development of the renal parenchyma due to abnormal differentiation, and pathological lesions include persistent foetal structures, dysplastic tubules and cartilaginous and osseus metaplasia. The aetiology of Renal dysplasia in dogs is still unknown, but possible causes are infection with canine herpesvirus, teratogenic substances or intrauterine ureteral obstruction. In some breeds Renal dysplasia is a familial or inherited disease. Clinical signs of chronic renal failure, such as polyuria, polydipsia, vomiting, weight loss, anorexia, lethargy and anemia, usually appear before the age of 2 years.

Renal dysplasi (RD) is a congenital chronic renal disease affecting young dogs. It is a rather common disease that occurs in a large number of dogs and in some breeds there is a familiar incidence or suspected hereditary background. Both the etiology and pathogenesis are still unknown, but a theory about the cause of RD is that the two components that form the kidney, the uretheric bud and the metanephrogenic blastema, don´t interact normally in the embryo. Kidneys affected by RD contain fetal (immature) structures that are inappropriate for the state of development/age of the dog and abnormal structures caused by an abnormal differentiation. Affected dogs usually are under .

Cirka 300 000 individer drabbas årligen i världen av oral cancer och mer än nittio procent av alla orala cancerformer utgörs av skivepitelcancer. Den femåriga prognosen är generellt 50 % och den 5-åriga relativa överlevnaden har under en tioårsperiod förblivit densamma. Detta motiverar utvecklingen av bättre prognostiska markörer och diagnostiska metoder för att tidigt identifiera de patienter som har risk att utveckla oral skivepitelcancer för att förbättra prognosen och minska lidandet genom tidig insatt behandling. ?-catenin är en adhesionsmolekyl som är viktig för bibehållandet av cellulär integration och avvikelser i celladhesionsmolekyler tros spela en central roll när tumörceller invaderar närliggande vävnad det vill säga metastaserar till andra organ. Syftet med studien är att med hjälp av immunohistokemi undersöka om ?-catenin kan fungera som en prognostisk markör för utvecklingen av oral skivepitelcancer.

This study examines if the prediction of cardiovascular disease in hypertensive patients can be improved upon when renal function and microalbuminuria are added to the classical risk factors The predictive capability of a model is measured by discrimination, calibration, reclassification and Harrell's C.The results are ambigious. In most cases, microalbuminuria should be included in the model, but the results regarding the other measures of renal function are varied. Therefore, the selection of risk factors to include in the model depends on which measure of prediction one prioritizes..

Bull terrier hereditary nephritis is caused by a mutation that leads to an inadequate synthesis of collagen type IV, which is an important component in the basement membranes. The inheritance of the mutation is autosomal dominant in bull terriers and progression to renal failure takes variable time, from several months to ten years. Proteinuria is the first clinical sign of the disease and the diagnosis is confirmed by transmission electron microscopy of renal tissue where typical ultrastructural changes in the glomerular basement membrane (GBM), thickening and multilaminar splitting are found. This study was performed in order to find out the occurrence of hereditary nephritis in bull terriers in Sweden through examination of urine samples and renal tissue and comparisons with how the disease is described in the literature. Urine samples from 76 Swedish bull terriers were collected and examined for proteinuria.

The occurrence of small amounts of albumin in urine, microalbuminuria (MA), is used both in human- and veterinary medicine as an indicator for patients who have developing proteinuria. Proteinuria can be prerenal, renal or postrenal which is important to establish during an investigation. With conventional methods decreased renal function is not detected until 70 % of renal function is lost. The ability to detect and start a treatment earlier might reverse or slow the progression of disease. The purpose of this study was to investigate the reliability of Heska® E.R.D.-Health Screen?, a test for microalbuminuria in dogs, to detect albuminuria.

Both serum creatinine and measuring GFR can be used to evaluate renal function in dogs suspected to have chronic kidney disease (CKD). Although high creatinine levels usually indicate renal disease, normal creatinine levels can be present in dogs with decreased renal filtration. Measuring GFR is generally believed to be the most accurate way of detecting decreased renal filtration and scintigraphy GFR using 99mTc-DTPA has been found to correlate well with the ?gold standard? inulin clearance method.When measuring GFR by scintigraphy, 99mTc-DTPA is injected intravenously and radioactive decay of technetium gives rise to gamma radiation, which is registered by a gamma camera. Pictures and curves of radioactivity in the kidneys are generated by means of a computer program.

Njurarna är två viktiga multifunktionella organ och alla sjukdomar som ger njurpåverkan kan resultera i nedsatt njurfunktion. Hur stort bortfall av njurfunktionen som åsamkats har betydelse för individens välmående och överlevnad, varför det är viktigt att tidigt upptäcka och behandla sjukdomen. Ärftliga njursjukdomar är i de flesta fall progressiva och i slutändan fatala. En ökad medvetenhet och kunskap om ärftliga njursjukdomar kan genom möjligheterna till ett förbättrat avelsarbete bidra till minskat lidande och ökad välfärd hos individerna i drabbade hundraser. I en ännu opublicerad svensk studie identifieras bl.a. raserna shetland sheepdog (SHS) och cavalier king charles spaniel (CKCS) som två av raserna med högst incidens av njursjukdom. Dessa två raser omnämns dock sällan som särskilt drabbade i den veterinärmedicinska litteraturen. Examensarbetets syfte var att utifrån journaler från två stora svenska djursjukhus (Evidensia Södra Djursjukhuset och Universitetsdjursjukhuset, Sveriges Lantbruksuniversitet) beskriva vilka njursjukdomar som diagnosticerats hos dessa raser samt undersöka om någon sjukdom verkade förekomma mer frekvent. Genom sökningar på njursjukdomsspecifika diagnoskoder i djursjukhusens journaldatabaser så återfanns de individer som senare inkluderades i studien.

Background: Diabetes mellitus is a chronic disease that manifests as an increased level of glucose in the blood. According to the World Health Organization (WHO), 347 million people have diabetes worldwide. In year 2004, 3.4 million people died from the consequences of high blood glucose. In the Swedish population the prevalence of diabetes is estimated to 3-4 %, out of which 85-90% are Type 2. Among senior citizens a prevalence of diabetes is seen in Sweden up to 14 - 15%.

Diseases associated with monocytosis in Swedish dogs - a retrospective study. The purpuse of this retrospective study is to determine which diseases are associated with pronounced monocytosis in Swedish dogs. Records of 153 dogs with monocytosis were evaluated. The most common cause was infectious diseases (49%) of which pyometra was seen in 23% of the cases, cystitis and fever of unknown origin each in 13% and gastroenteritis in 12%. Cortison treatment was the second most common cause with 29%. A sixth of the dogs had non inflammatory diseases such as neoplasia, renal- and heartfailure.

The WT1 gene is a complex gene originally known to suppress cancer in kidneys. Studies of WT1 knockout mice have confirmed the important role of WT1 in the pathogenesis of Wilms? tumour, a tumour which counts for 95% of all childhood renal tumours. In that case the WT1 gene acts as a tumour suppressor gene. Subsequent research has shown that the WT1 gene in many other cases acts as an oncogene, e g in leukemia or lung cancer (even though these cancer forms can emerge as a result of many other aetiological factors).

Detta examensarbete är gjort som en utredning i samarbete med Stora Enso Bioenergi AB (SEBAB) och är utfört i region väst, omfattande Dalsland och Värmland. Med dagens klimatdebatt och industrins allt mer växande intresse för förnyelsebara energikällor talas nu om en skiftning i användandet av fossila bränslen till fördel för mer uthålliga alternativ. Ett av dessa alternativ är hyggesrester i form av grenar och toppar (grot). Innan avverkning sker har en uppskattning gjorts rörande mängden potentiell uttagbar grot på en trakt. Efter att uttag skett och groten flisats och inmätts har SEBAB kunnat se stora skillnader mellan den första framräknade mängden och den slutliga inmätta.

Bakgrund: I Sverige drabbas varje år 600 personer av kronisk njursvikt. Ett tillstånd som bidrar till att blodet inte renas från restprodukter. För att ersätta njurarnas förlorade funktion kan hemodialys utföras, en behandling som blir en stor del av patienternas vardag. Med god insikt kring hemodialys kan sjuksköterskan möta patientens sjukdomsupplevelse och lidande och så långt som möjligt lindra detta genom adekvata åtgärder. Syftet: Syftet var att belysa patienters upplevelse av att leva med hemodialys i det dagliga livet.

Njurbiopsi tas för att ställa diagnos och för behandlingskontroll av flera njursjukdomar. En del av sjuksköterskans arbete att förbereda och övervaka patienter. Njurbiopsi är förenat med risken att drabbas av en blödning vilken kan vara livshotande. I Sverige tycks vården vid njurbiopsi skilja sig åt mellan olika sjukhus. Det saknas en systematisk sammanställning av praxis.